Question: Is There A Substitute For Clopidogrel?

Is clopidogrel the same as aspirin?

Aspirin and Plavix (clopidogrel bisulfate) are drugs used to prevent blood clots.

Aspirin and Plavix belong to different drug classes.

Plavix is an anticoagulant and aspirin is a nonsteroidal anti-inflammatory drug (NSAID).

Aspirin also is used to reduce fever, and to treat pain and inflammation in the body..

How long can you stay on clopidogrel?

The key question for your doctor is whether the benefits outweigh the extra risk. This combination treatment is prescribed for a limited period of time, usually up to a maximum of 12 months. After this period, your specialist will usually advise you to stop 1 of the 2 antiplatelet medications.

Why is clopidogrel and aspirin used together?

The combination of clopidogrel and aspirin may lower the risk for major ischemic events among patients with minor ischemic stroke or high-risk transient ischemic attack compared with aspirin alone, according to results of the POINT study.

What are the side effects of stopping clopidogrel?

Among the types of withdrawal is one that is sometimes termed rebound (Medicine Induced Stress Syndromes, Dependence and Withdrawal). This can lead to rebound heart rate increases in drugs like beta-blockers that slow heart rate and rebound clotting in drugs that reduce clotting.

Does clopidogrel affect the liver?

The severity of liver injury associated with clopidogrel ranges from transient, mild serum enzyme elevations to clinically apparent acute hepatitis that can be severe and lead to death. Most cases resolve with drug withdrawal within 1 to 3 months.

Can you take clopidogrel every other day?

Conclusions: Long term dual anti-platelet therapy with aspirin 81 mg daily and clopidogrel 75 mg every other day beyond 12 months after PCI with DES may be a safe and efficacious cost-saving strategy to prevent VLST.

Does clopidogrel affect blood pressure?

Arterial hypertension is associated with platelet activation, increased sCD40L levels and endothelial dysfunction suggesting that inhibition of platelet-derived sCD40L release may improve endothelial function and lower blood pressure (BP).

Which is better aspirin or clopidogrel?

Clopidogrel is another guideline‐recommended antiplatelet agent21 and has been shown to be superior to aspirin in preventing composite vascular events and reducing hemorrhagic complications in a randomized controlled trial, CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events).

How do you reverse clopidogrel?

There are no specific reversal agents for clopidogrel. Since its effects are irreversible, the resultant platelet inhibition lasts for the lifespan of the platelet, ∼7–9 days.

Does clopidogrel cause joint pain?

Arthralgia and backache are also known to occur with its use. There have been case reports linking arthritis with the use of clopidogrel. We describe the case of a 64-year-old man who reported symptoms of fever and joint pains following initiation of therapy with clopidogrel. Acute-phase reactants were elevated.

Can clopidogrel be stopped?

Do not stop taking clopidogrel without talking to your doctor. If you stop taking clopidogrel, the rate at which your blood clots will return to what it was before you started taking it – usually within 5 days of stopping. This means you may be at increased risk of serious problems like heart attacks or strokes.

What is the trade name for clopidogrel?

Clopidogrel oral tablet is available as both a generic and brand-name drug. Brand name: Plavix. Clopidogrel only comes in the form of a tablet you take by mouth. Clopidogrel is used to prevent heart attack and stroke.

Can you still have a stroke if you are on blood thinners?

Unfortunately, the blood thinners used to prevent such blood clots can increase the risk of bleeding in the brain, a cause of hemorrhagic stroke.

Do blood thinners shorten your life?

Blood thinning medications do save lives, because they can treat or prevent dangerous blood clots. But, they also pose one possible and very serious side effect: Bleeding. Since blood thinners slow the clotting of blood, unwanted and sometimes dangerous bleeding can occur with the use of these medications.

When Should clopidogrel be stopped?

It carries a high risk of bleeding, but the patient is by definition at high risk for ischaemic events. Although aspirin can be continued in patients undergoing cardiac surgery, clopidogrel should be stopped at least 5 days before the procedure when the surgery is scheduled and the risk of ischaemia is low.

Is it safe to take clopidogrel long term?

Safety Announcement [ 11-06-2015 ] A U.S. Food and Drug Administration (FDA) review has determined that long-term use of the blood-thinning drug Plavix (clopidogrel) does not increase or decrease overall risk of death in patients with, or at risk for, heart disease.

Does clopidogrel affect kidney function?

Conclusions. In summary, among patients hospitalized with ACS and treated with clopidogrel, lower levels of kidney function were associated with a greater risk of death, hospitalization for AMI, and major bleeding.

Can I drink coffee with Plavix?

Conclusions: Acute caffeine administration after clopidogrel loading appears to be associated with enhanced platelet inhibition 2 to 4 hours after clopidogrel intake. The mechanism probably involves synergistic increase in cAMP levels.